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The year is 2048. Earth is horribly overpopulated and dwindling resources force scientists to look to the stars for mankind's survival. Military officer Rick Janssen (Sam Worthington) and his wife Abigail (Taylor Schilling) leave Los Angeles in the aftermath of a devastating nuclear event to start anew at a Nato base. In this carefully controlled environment, Professor Martin Collingwood (Tom Wilkinson) is overseeing a top-secret government-funded programme to ready servicemen and women for a new life on Saturn's moon Titan. The moon's atmosphere is far different to Earth so Rick receives a series of injections that should allow him to breathe the nitrogen-heavy air. In fact, the programme is designed to transform unwitting subjects into an alien-human hybrid christened Homo Titanians. Rick undergoes shocking physical mutations and Abigail breaks into Professor Collingwood's laboratory to learn the shocking truth about her husband's grim fate.